Vivian’s great voice and cute face are the catalysts of her performance in the music industry in both Hong Kong and Macau, and she successfully collected a number of hits such as Eventually and Self-Camera. Her passion for music and courage to challenge led her to singing contests. Since finishing tenth in The Voice 2, she made her official debut in Hong Kong later in 2013 and released the first album under her name. In 2014, Vivian was crowned the champion of The Voice of China (Macau Audition).

Vivian’s second solo album A Nobody was released in 2015 and she had her very first concert titled Flight Mode, leading the audience to enter a world solely filled with music without any other noises to seek our ultimate innocence. She has participated in a number of micro films and musicals. She was the leading role in the musical Dreamers! Go! Go! for twice. In addition, she made her movie debut playing the leading role for the first time in Guia in Love, and she took part in several movies such as Return of the Cuckoo and 29+1. She also dubbed for the movie Sky on Fire in Cantonese. Meanwhile, she is the vice president of Macau Artistes Association.

Despite her success in the acting career, she still persists in bringing good music to everyone. In 2016 and 2017, she released two self-composed songs – The Wish of Ho Jai and Lee Lo May, and received over 100 thousands views. In 2017, she collaborated with Pai LeaDer and released Children's Song Medley, which reached more than 2 million views. She also released her third album A Particle and held her first concert We Are Silly in Hong Kong.

擁有悅耳歌聲和可愛樣貌的陳慧敏活躍於港澳樂壇，主唱多首大熱得獎作品，包括《始終》、《自拍》等。熱愛音樂的她喜歡挑戰自己，曾參與多個大型歌唱比賽。其中，她透過參加《超級巨聲2》入選十強，並於2013年正式到香港發展，同年推出首張同名個人專輯。2014年，陳慧敏成為《中國好聲音》澳門站總冠軍。

陳慧敏於2015年正式發行第二張個人專輯《小人物》，同年舉辦首次個人音樂會《飛航模式》，透過歌聲帶領觀眾進入一個只有音樂、沒有雜音的空間，讓內心回復最真摯的尋覓。在影視上，陳慧敏曾多次參與音樂劇演出，包括四年參與《芝麻高高音樂劇》的演出，更擔任其中兩年女主角的角色。她更首次在電影《燈塔下的戀人》飾演女主角，亦參與多部電影演出如《十月初五的月光》、《29+1》等等，也為電影《沖天火》女主角作粵語配音。她同時為擔任澳門演藝人協會的副會長。

在發展演藝事業的同時，她亦不忘把好音樂傳到每人心中。2016年，她於網上發佈《濠仔的心願》、《李路微》等等個人創作歌曲，在網上瀏覽人數每首為十至二十多萬不等。2017年和排長合作發佈《兒歌串燒》影片更在網上被瘋傳，瀏覽人數總和達二百萬。同年發佈第三張個人創作專輯《一粒嘢》，更於11月1日在香港舉行首個公開售票個人演唱會《我們叫傻瓜》，大獲好評。